Alpha-7 Nicotinic Receptor

The alpha-7 nicotinic receptor is commonly known as the α7 receptor. It is a long-term memory consisting of α7 subunits. It is a type of nicotinic acetylcholine receptor (nAChRs), a polypeptide responsible for responding to neurotransmitter acetylcholine receptors. But with other the nAChRs, the α7 receptor is pentameric (A protein structure that contains five protein subunits).  It is found in lymphocytes, lymph nodes, brain, and spleen. It is activated mainly due to a gradual increase in Ca2+ permeability. Recent studies show that the Alpha-7 nicotinic receptor is essential for the production of adult mammal neurons in the retina. The functional Alpha-7 receptors are located in submucous plexus neurons. Recent research shows that this Alpha-7 nicotinic receptor plays a vital role in reducing inflammation, Alzheimer’s disease, stroke, and myocardial infarction (a type of heart attack). It also shows promising effects on neurocognition in a person suffering from Schizophrenia.  The activation of the Alpha-7 nicotinic receptor is a mechanism that enhances atherosclerosis. Both the α7 receptor and the α4β2 receptor play an important role in learning, attention, and memory. The Alpha-7 nicotinic receptor is also involved in the progression of a serious disease like cancer.

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