Chemokines

Chemokines are small proteins that come under the category of cytokines. They are found to be of 8-10 kilodaltons and contains four cysteine residues in some conserved spots that play a significant role in forming their 3-D structure. Chemokines are present in all vertebrates, some viruses, and some bacteria. These proteins function to induce directed chemotaxis to nearby responsive cells; hence, they have been involved in cell motion initiation due to chemical responses. Their major function is to influence your immune system as it directs cell migration back and forth via venules from the blood to the respective tissue and also regulates lymphoid organ development and T-cell differentiation. Chemokines bound g protein-coupled receptors on target cells, so they are also known as chemokine receptors. Chemokine receptors are situated at the surface of target cells. These proteins are also discovered as the mediators in the accurate migration of cells of the immune system to active sites like inflammation or injury and also regulate mediate tumor cell metastasis. During normal-healthy conditions, they are involved in the maintenance and development of the tissues. In the nervous system, chemokines are regarded as neuromodulators and aids in its functioning.

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