Low-affinity nerve growth factor receptor

Low-affinity nerve growth factor receptor (LNGFR) is the 16th member of the TNFR (tumor necrosis factor receptor) superfamily. LNGFR is also known as the p75 neurotrophin receptor. It belongs to the family of the protein responsible for the differentiation and survival of the neural cells. LNGFR is a member of the TNFR superfamily and also the first characterized member of this superfamily.  

Neurotrophins comprise four major proteins Brain-derived nerve growth factor (BDNF)Nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and all these four protein binds to LNGFR. NGF is a protein, i.e., secreted by a neuron's target, and thus it is a prototypical growth factor. The presence of NGF is essential for the survival of the sensory neurons. But the NGF binds two receptors TrkA and LNGFR, which is responsible for responding to growth factors. 

Neurotrophins that activate LNGFR may result in a cell's death due to apoptosis, but TrkATrkB, and TrkC prevent it from getting dead. LNGFR plays an important role in activating the pathways which are responsible for the developmental Axon pruning and in degeneration of the neurodegenerative disease.  

Recent studies have shown that LNGFR plays a vital role in the development of sensory and eye neurons and also helps in repairing muscles and damages in the nerve. 

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